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The study comprised 12 dogs, including four groups with various modifications incorporating KindredBio technology and one wild type canine antibody as control. Half-life extension was observed in all dogs across all groups other than the wild type, with the magnitude of extension over native antibody ranging from two to three-fold. Additional studies to further differentiate between lead molecules and expand sample size are planned for 2020.
Half-life extension technologies have the potential to improve therapeutic performance in numerous ways. Reduced dosing frequency and/or amount of dosing can lead to improved patient convenience and compliance. It can also substantially lower the cost of goods and enhance profitability and market positioning. In addition, higher drug concentration using the same dose and dosing interval as the parent antibody can result in extended drug exposure and potentially improved efficacy.
"This innovation is a major breakthrough, with wide-ranging impact across our biologics portfolio," said KindredBio's Chief Executive Officer,
"We expect longer-lasting therapeutics and improved convenience to accelerate the shift to antibody-focused veterinary medicine. KindredBio is proud to be a leader in companion animal biologics, with a deep pipeline, state-of-the-art biologics manufacturing capabilities, and a world-class team of protein engineers."
KindredBio's canine biologics pipeline includes treatments in development for atopic dermatitis, inflammatory bowel diseases and parvovirus.
KindredBio will discuss and answer questions on the results of the study today at
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The results stated in this press release have not been reviewed by the
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